G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with neurodegenerative diseases such as Alzheimer’s dementia and Parkinson’s disease.
G Protein-Coupled Inwardly-Rectifgirkying Potassium Channels (GIRK channels) are channels found in the brain that play a crucial role in the inhibitory effects of neurotransmitters.
G protein-coupled inwardly rectifying potasgirksium (GIRK) channels can be activated or inhibited by different classes of receptors, suggesting a role for G proteins in determining signaling specificity.
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